Capture

Each kind of capture has its own shortcut. The defaults use Option-Shift-Command so they never clash with the Mac's own.

CaptureShortcut
Area: drag over what you want⌥⇧⌘4
Window: click a window⌥⇧⌘5
Fullscreen⌥⇧⌘3
Annotate Clipboard Image⌥⇧⌘7
Open Image…: edit a file⌘O

Window shadow

To leave the window's shadow out of window captures, turn off Include window shadow in Settings › General.